<Emphasis Type="Italic">C. elegans dss-1</Emphasis>is functionally conserved and required for oogenesis and larval growth |
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| Authors: | Johanna Pispa Susanna Palmén Carina I Holmberg Jussi Jäntti |
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| Institution: | (1) Cellular Biotechnology Research Program, Institute of Biotechnology, University of Helsinki, Helsinki, Finland;(2) Molecular Cancer Biology Program, and Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland |
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| Abstract: | Background Dss1 (or Rpn15) is a recently identified subunit of the 26S proteasome regulatory particle. In addition to its function in
the protein degradation machinery, it has been linked to BRCA2 (breast cancer susceptibility gene 2 product) and homologous
DNA recombination, mRNA export, and exocytosis. While the fungal orthologues of Dss1 are not essential for viability, the
significance of Dss1 in metazoans has remained unknown due to a lack of knockout animal models. |
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