产琥珀酸放线杆菌发酵生产琥珀酸的研究进展

近年来，因瘤胃微生物产琥珀酸放线杆菌Actinobacillus succinogenes具有高的琥珀酸产量，并能够利用多种碳源进行发酵等优点，在利用发酵法生产琥珀酸领域具有广泛的应用前景和商业化价值，因而其代谢途径和发酵工艺等基础研究成为国内外研发的热点。近年来，人们在产琥珀酸放线杆菌的代谢途径、琥珀酸发酵动力学模型、新型经济培养基以及高产菌株选育等方面的研究取得了很大进展，对研发琥珀酸发酵工艺、降低生产成本和节能减耗等具有重要的理论意义。

Research Progress in Succinic Acid Fermentation of Actinobacillus succinogenes

Actinobacillus succinogenes was isolated from the bovine rumen and has a great prospect on the succinic acid fermentation. Due to its high yield and fermentation with a broad range of carbon source, the metabolic pathway and fermentation of Actinobacillus succinogenes has become the research hotspot in succinic acid fermentation, recently .The research on Actinobacillus succinogenes is reviewed in this paper, which includes the development of metabolic pathway, the kinetic model of succinic fermentation, the novel and economic mediums and the screening of high yield strains. These results significantly increase the productivity according to the strain reconstructing and the reasonable fermentation technologies designing.