The purine path to chemotherapy |
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| Authors: | Gertrude B Elion |
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| Institution: | (1) Wellcome Research Laboratories, Burroughs Wellcome Co, 3030 Cornwallis Road, 27709 Research Triangle Park, NC, USA |
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| Abstract: | Antimetabolites of purine metabolism have found a use as anti-leukaemic, antiprotozoal and antiviral drugs, in immunosuppression and transplantation, and in gout and hyperuricemia. Their mechanisms of action are reviewed.Nobel Lecture given on December 8, 1988; by Dr Gertrude B. Elion and published inLes Prix Nobel 1988, printed in Sweden by Norstedts Tryckeri, Stockholm, Sweden, 1989, republished here with the permission of the Nobel Foundation, the copyright holder. |
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| Keywords: | purine antimetabolite chemotherapy anti-leukaemic drug antiprotozoal drug antiviral drug acyclovir |
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