Relationships Between Respiratory Function Disorders and Serum Copper Levels in Copper Mineworkers |
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Authors: | Abdurrahman Abakay Osman Gokalp Ozlem Abakay Osman Evliyaoglu Cengizhan Sezgi Yilmaz Palanci Faysal Ekici Askeri Karakus Abdullah C Tanrikulu Mustafa Ayhan |
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Institution: | (1) Department of Chest Diseases, Medical Faculty, Dicle University, Diyarbakir, Turkey;(2) Department of Pharmacology, Medical Faculty, Dicle University, Diyarbakir, Turkey;(3) Department of Chest Diseases, Education and Training Hospital, Diyarbakir, Turkey;(4) Department of Biochemistry, Medical Faculty, Dicle University, Diyarbakir, Turkey;(5) Department of Public Health, Medical Faculty, Dicle University, Diyarbakir, Turkey;(6) Department of Radiology, Medical Faculty, Dicle University, Diyarbakir, Turkey;(7) Department of Mine Engineering, Dicle University, Diyarbakir, Turkey |
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Abstract: | The aim of this study was to investigate the respiratory function disorders that could be related to dust exposure during
the production of copper mine in copper mineworkers (CMWs). The study included 75 male CMWs (mean age, 32.0 ± 7.1 years, 58.6%
smokers) and 75 male age- and smoking status-matched healthy control subjects. Serum Cu level was significantly higher in
the CMW group (0.80 ± 0.62 μg/ml) than the control group (0.60 ± 0.39 μg/ml) (p = 0.017). Significant negative correlations were found between serum Cu level and forced expiratory volume in first second
(r = −0.600; p < 0.001) and between serum Cu level and forced vital capacity (r = −0.593; p = <0.001) in CMWs. Serum Cu level was significantly higher in the restrictive type pulmonary function disorders group (1.36 ± 0.62 μg/ml)
than obstructive type (0.90 ± 0.55 μg/ml) and normal pulmonary function pattern group (0.53 ± 0.43 μg/ml) (p < 0.001). Patients with radiological parenchymal abnormalities had significantly higher serum copper levels than those without
abnormalities (1.53 ± 0.52 vs. 0.71 ± 0.52 μg/ml, respectively; p = 0.002). In conclusion, result of the study has shown a negative association between pulmonary functions disorders and radiological
abnormalities and serum Cu levels in CMWs. |
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