An extension of the coevolution theory of the origin of the genetic code |
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Authors: | Massimo Di Giulio |
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Institution: | (1) Laboratory for Molecular Evolution, Institute of Genetics and Biophysics 'Adriano Buzzati Traverso', CNR, Via P. Castellino, 111, 80131 Naples, Napoli, Italy |
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Abstract: | Background The coevolution theory of the origin of the genetic code suggests that the genetic code is an imprint of the biosynthetic
relationships between amino acids. However, this theory does not seem to attribute a role to the biosynthetic relationships
between the earliest amino acids that evolved along the pathways of energetic metabolism. As a result, the coevolution theory
is unable to clearly define the very earliest phases of genetic code origin. In order to remove this difficulty, I here suggest
an extension of the coevolution theory that attributes a crucial role to the first amino acids that evolved along these biosynthetic
pathways and to their biosynthetic relationships, even when defined by the non-amino acid molecules that are their precursors. |
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Keywords: | |
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