Development of intracytoplasmic lumina in diethylnitrosamine-induced tracheal papillomas of Syrian golden hamster

Tracheal papillomas in the Syrian golden hamster were induced with diethylnitrosamine (DEN). Intracytoplasmic lumina filled with mucus were studied by light and electron microscopy. The sequence of lumen genesis is described ultrastructurally. Mucus substances in the center of intracytoplasmic lumen are presumed to be condensations of cell coat macromolecules. The intracytoplasmic lumen is discussed as a common feature of the adenoid component in epithelial neoplasms.