铜绿假单胞菌的双组分系统

双组分系统是存在于原核和少部分真核生物细胞中的信号转导系统，主要由组氨酸蛋白激酶和反应调节蛋白组成，通过感应外界环境信号、信号输入、磷酸基团传递、信号输出等环节调节基因表达，使细胞能更加适应环境变化。铜绿假单胞菌为条件致病菌，其双组分系统构成多样、功能复杂且参与介导耐药性产生，因此铜绿假单胞菌的双组分系统日益引起人们关注。本文对铜绿假单胞菌双组分系统的组成、信号转导机制、种类、研究方法及其临床意义进行了综述。

The two-component regulatory systems in Pseudomonas aeruginosa

Two-component regulatory system exists in both Prokaryotes and eukaryotes, which is mainly composed with HPK and RR. By means of the signal input, phosphorylation, and output, it can regulate the adaptability of ceils to the environment. As a major opportunistic pathogen, Pseudomonas aeruginosa is one of the main pathogens of nosocomial infection. Its drug-resistant strains increase year by year, the two-component system of which involved in the generation of drug resistance. Since the two-component system is essentially different from the system in human cells in signal transduction, finding a new antibiotic target has great potential.