Modulation of spiking of neurons of the cat anterior hypothalamus induced by experimental shifts in the osmolarity of the blood plasma |
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Authors: | L V Natrus |
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Institution: | (1) Donetsk State Medical University, Ministry of Public Health of Ukraine, Ukraine |
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Abstract: | We examined changes in the impulse activity (IA) generated by neurons of the anterior hypothalamus (including the preoptic
region) resulting from infusions of hyper-and hypotonic NaCl solutions (3.0 and 0.2%, respectively; hyper-and hypoosmotic
stimulations, respectively); the infused volumes did not exceed 200 μl. The effects of hyper-and hypoosmotic stimulations
were studied in detail in 83 and 88 neurons, respectively. In 31.2% (26 cells) and 29.6% (26 cells) of the neurons of the
above groups, these stimulations evoked changes in the IA frequency greater than +40 or −40% of the mean background IA frequency.
In approximately 50% of the responding neurons in each group, such shifts in the IA frequency were observed in the course
of infusions of test solutions (5 sec long) and within the subsequent 5 min after termination of the infusion. In another
50% of the neurons, changes in the IA frequency occurred within the afterperiod (30 sec long); these shifts could develop
exclusively within the latter interval, or these changes accompanied an initial early reaction. In general, activating responses
dominated (they were observed in 65% of the cases where test stimulations of both modalities were used). The possible aspects
of the involvement of neurons of the anterior hypothalamus in the control of the water/salt balance in the organism are discussed.
Neirofiziologiya/Neurophysiology, Vol. 38, No. 1, pp. 40–45, January–February, 2006. |
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Keywords: | water/salt balance hypothalamus hyperosmia hypoosmia impulse activity mean frequency drink behavior |
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