Network properties of human disease genes with pleiotropic effects |
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Authors: | Sreenivas Chavali Fredrik Barrenas Kartiek Kanduri Mikael Benson |
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Institution: | (1) The Unit for Clinical Systems Biology, University of Gothenburg, Medicinaregatan 5A, Gothenburg, SE405 30, Sweden |
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Abstract: | Background The ability of a gene to cause a disease is known to be associated with the topological position of its protein product in
the molecular interaction network. Pleiotropy, in human genetic diseases, refers to the ability of different mutations within
the same gene to cause different pathological effects. Here, we hypothesized that the ability of human disease genes to cause
pleiotropic effects would be associated with their network properties. |
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Keywords: | |
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