Serum and urinary estrone sulfate during the menstrual cycle, measured by a direct radioimmunoassay, and fate of exogenously injected estrone sulfate |
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| Authors: | H Honjo J Kitawaki M Itoh J Yasuda K Iwasaku M Urabe K Naitoh T Yamamoto H Okada T Ohkubo |
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| Institution: | Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Japan. |
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| Abstract: | Serum and early-morning urinary levels of estrone sulfate during the menstrual cycle were measured by a direct radioimmunoassay without hydrolysis. These levels were high and showed prominent peaks serum, 2.67 +/- 0.37 ng/ml (mean +/- SE); urine, 5.82 +/- 2.3 micrograms/l] around the day of the preovulatory estradiol-17 beta peak, and increased again during the luteal phase. Following intravenous injection of estrone sulfate, serum estrone sulfate, estrone and estradiol-17 beta were measured. The conversion of estrone sulfate to estrone and/or estradiol-17 beta was very small during their transit in the general circulation. |
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