Inhibitory effect of amines on polar filament extrusion byPlistophora anguillarum spores |
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Authors: | Koohei Hashimoto Yukio Sasaki Kooichi Takinami |
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Institution: | (1) Central Research Laboratories of Ajinomoto Co., Inc., 210 Kawasaki, Japan |
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Abstract: | In in vitro tests, amines were screened for the inhibition of polar filament extrusion by spores ofPlistophora anguillarum, a microsporidian parasite of the eel. Primary amines having C8
− C18 alkyl chains were effective, irrespective of the anions bound. Secondary amines having a branched C8 chain and tertiary amines having C14−C18 chains were also effective. Asymmetry in side chains seemed to be required for inhibitory action. Quaternary ammonium salts
having C12−C16 alkyl chains and some germicides or disinfectants such as cetyl pyridinium chloride and benzethonium chloride were also effective.
Diamines and amides were ineffective regardless of the length of their alkyl chins. In in vivo tests, eel larvae-fed for 4
days with a commercial feed supplemented with 5×108 cells of spores and 4g of laurylamine aspartate/100 g feed, and thereafter with the usual commercial feed for 26 days—were
not infected. |
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