| 抗胰腺星状细胞药物研究进展 |
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| 引用本文： | 杨丽娟,王兴鹏.抗胰腺星状细胞药物研究进展[J].现代生物医学进展,2012,12(25):4981-4984. |
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| 作者姓名： | 杨丽娟 王兴鹏 |
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| 作者单位： | 上海交通大学附属第一人民医院消化科;同济大学附属第十人民医院消化科 |
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| 摘 要： | 慢性胰腺炎传统治疗方法效果不确定,需要寻找新型有效药物。活化的胰腺星状细胞在胰腺纤维化过程中起了重要的作用,使之成为新的治疗靶点。活化PSC的物质分为三类,即炎症介质、氧化应激和毒素。本文就近年来针对以上不同活化PSC的介质和相关通路的抗星状细胞药物进行综述。
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| 关 键 词： | 慢性胰腺炎 纤维化 胰腺星状细胞 |
Advances in Pharmacological Agents Aimed at Preventing Pancreatic
Stellate Cell Activation |
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| YANG Li-juan,WANG Xing-peng.Advances in Pharmacological Agents Aimed at Preventing Pancreatic
Stellate Cell Activation[J].Progress in Modern Biomedicine,2012,12(25):4981-4984. |
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| Authors: | YANG Li-juan WANG Xing-peng |
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| Institution: | 1,2(1 Department of Gastroenterology,the First People’ s Hospital,Shanghai Jiao Tong University,Shanghai 200080,China; 2 Department of Gastroenterology,the Tenth People’ s Hospital,Tongji University,Shanghai 200072,China) |
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| Abstract: | The efficacy of current treatment of chronic pancreatitis is poor.With the discovery of pancreatic stellate cell(PSC) and some understanding of the molecular mediators and pathways involved in the pathogenesis of chronic pancreatitis(CP),inhibition of the activation and functions of PSC has become a potential goal directed to the treatment and prevention of pancreatic inflammation and fibrosis.This review summarizes the current literature addressing the role of different pharmacological agents aimed at preventing activa-tion of PSC. |
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| Keywords: | Chronic pancreatitis Fibrosis Pancreatic stellate cells |
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