| 凋亡抑制蛋白XIAP 在急性髓系白血病和淋巴瘤骨髓组织中的表达及意义 |
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| 引用本文： | 黄闪王瑾李登举曹阳周晓曦李钦璐姜利军周剑峰徐丹梅. 凋亡抑制蛋白XIAP 在急性髓系白血病和淋巴瘤骨髓组织中的表达及意义[J]. 现代生物医学进展, 2012, 12(20): 3857-3859 |
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| 作者姓名： | 黄闪王瑾李登举曹阳周晓曦李钦璐姜利军周剑峰徐丹梅 |
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| 作者单位： | 华中科技大学附属同济医院血液科 |
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| 摘 要： | 目的:研究凋亡抑制蛋白(XIAP)在白血病及淋巴瘤骨髓活检组织中的表达及意义。方法:采用免疫组织化学法检测10例急性髓系白血病,13例淋巴瘤,9例非恶性血液病患者骨髓活检组织中XIAP的表达水平。结果:XIAP蛋白在急性髓系白血病、淋巴瘤骨髓活检组织中的阳性表达积分均高于非恶性血液病,差异均有统计学意义(P<0.05)。结论:XIAP的表达水平与白血病及淋巴瘤的发生发展有一定关联,可能与其抑制肿瘤细胞的凋亡有关。
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| 关 键 词： | 白血病 淋巴瘤 XIAP |
Expression and Clinical Significance of XIAP Protein in the BoneMarrow Tissue of Acute Myeloid Leukemia and Lymphoma |
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| HUANG Shan,WANG Jin,LI Deng-ju,CAO Yang,ZHOU Xiao-xi,LI Qin-lu,JIANG Li-jun,ZHOU Jian-feng,XU Dan-mei. Expression and Clinical Significance of XIAP Protein in the BoneMarrow Tissue of Acute Myeloid Leukemia and Lymphoma[J]. Progress in Modern Biomedicine, 2012, 12(20): 3857-3859 |
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| Authors: | HUANG Shan WANG Jin LI Deng-ju CAO Yang ZHOU Xiao-xi LI Qin-lu JIANG Li-jun ZHOU Jian-feng XU Dan-mei |
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| Affiliation: | (Department of Hematology,Tongji Hospital,Wuhan,Hubei 430030) |
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| Abstract: | Objective: To investigate the expression and clinical significance of the X-linked inhibitor of apoptosis protein(XIAP) in bone marrow biopsy tissue of acute myeloid leukemia and lymphoma.Methods: The expression of XIAP was detected by immunohistochemical assay in the bone marrow biopsy tissue from 10 cases of acute myeloid leukemia,13 lymphoma and 9 patients without hematological malignancy.Results: The level of XIAP in the bone marrow tissue from acute myeloid leukemia and lymphoma was higher than those from control cases without hematological malignancy(P<0.05).Conclusion:The increased expression of XIAP protein may contribute to the progression of acute myeloid leukemia and lymphoma,which may be relevant to its role as inhibitor of apoptosis. |
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| Keywords: | Acute myeloid leukemia Lymphoma XIAP |
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