Wnt 信号通路与骨髓间充质干细胞成骨之间的关系

Wnt信号通路是由Wnts诱发的一系列相互作用的分子组成。Wnt信号对骨髓间充质干细胞的影响在所有研究中均证实有明显作用,其可调节干细胞增殖、分化及凋亡。研究表明,抑制Wnt信号通路转导可使成骨细胞分化进程受阻,从而抑制骨形成;若诱导Wnt家族成员表达则可使成骨细胞特异性基因表达增加,促进骨形成。本文就Wnt信号通路的作用过程及其与骨髓间充质干细胞成骨诱导的关系做一综述。

The Relationship between Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cell and Wnt Signal Pathways

The component of Wnt signal pathways is some interactional molecules induced by Wnts.All previous researches have indicated that Wnts have apparently effects on the biological behavior of bone marrow mesenchymal stem cell(BMSCs).Wnts could regulate cell growth,differentiation and apoptosis.The inhibition of Wnt signal pathways will lead to the osteogenic process delay,and the bone formation will be blocked.On the other hand,if we induce the opening of Wnts pathway,the specific osteogenic genes of osteoblast will show high expression and the bone formation will be promoted.A key remaining question is how Wnt signal pathways work during the osteogenic process of BMSCs.In this report,we reviewed the previous relative studies which investigated the Wnt-receptor binding system and the downstream intracellular response,and the relationship between osteogenic differentiation of bone marrow mesenchymal stem cell and Wnt Signal Pathways were also described in this report.