| 南京地区青年乳腺癌患者GSTM1、GSTT1 基因多态性与易感性
的初步研究 |
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| 引用本文： | 范滨,唐金海,吴建中,王卓,薛琏.南京地区青年乳腺癌患者GSTM1、GSTT1 基因多态性与易感性
的初步研究[J].现代生物医学进展,2012,12(25):4813-4815. |
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| 作者姓名： | 范滨 唐金海 吴建中 王卓 薛琏 |
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| 作者单位： | 徐州医学院研究生院;江苏省肿瘤医院普外科;江苏省肿瘤医院科研科 |
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| 基金项目： | 国家自然科学基金项目(30840093);江苏省社会发展科技计划项目(BS2007077) |
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| 摘 要： | 目的:研究GSTM1、GSTT1基因多态性与乳腺癌遗传易感性的关系。方法:应用PCR技术检测乳腺癌组和对照组人群GSTM1和GST T1基因。结果:GSTM 1和GSTT 1基因缺失率在乳腺癌组分别为63.4%(59/93)和54.8%(51/93),对照组分别为39.3%(35/89)和33.7%(30/89),两组比较,差异有统计学意义(P<0.01或P<0.05)。结论:GSTM1和GST T1缺失为乳腺癌遗传易感因素。
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| 关 键 词： | 乳腺癌 GSTM1 GSTT1 基因多态性 |
A Preliminary Study on the Relationship between Genetic Polymorphism of
Glutathione-S transferases T1, M1genes and Susceptibility of Young Female
Breast Cancer in Nanjing Area* |
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| FAN Bin,TANG Jin-hai,WU Jian-zhong,WANG Zhuo,XUE Lian.A Preliminary Study on the Relationship between Genetic Polymorphism of
Glutathione-S transferases T1, M1genes and Susceptibility of Young Female
Breast Cancer in Nanjing Area*[J].Progress in Modern Biomedicine,2012,12(25):4813-4815. |
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| Authors: | FAN Bin TANG Jin-hai WU Jian-zhong WANG Zhuo XUE Lian |
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| Institution: | 1 Xuzhou Medical College,Jiangsu Xuzhou 221004 China;2 Department of General Surgery,Jiangsu Cancer Hospital,Jiangsu,Nanjing 210009,China;3 Department of scientific research,Jiangsu cancer hospital,Jiangsu,Nanjing,210009,China) |
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| Abstract: | Objective: To examine the relationship of genetic polymorphisms of glutathione S-transferase(GST) including GSTM1 and GSTT1 and the susceptibility to breastcancer.Methods: A case-control study was designed and the absence of GSTM1 and GSTT1 genes were detected with PCR technique in 93 cases and 89 conrols.Results: The results showed that the ratios of GSTM1 null genotype in cases was 63.4%(59/ 93) and the ratios of GSTT1 null genotype in cases was 54.8%(51/93),while,those of controls were 39.3%(35/ 89) or 33.7%(30/89),P< 0.05.Conclusion: GSTM1 and GSTT1 null may be an important host risk factor for breastcancer. |
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| Keywords: | Breastcancer GSTM1 GSTT1 Genetic polymorphism |
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