儿童急性淋巴细胞白血病对预后的影响分析

目的:探讨儿童急性淋巴细胞白血病分型对预后的影响,为临床治疗提供依据.方法:回顾性分析2007年1月～2008年12月我院收治的急性淋巴细胞白血病患儿32例,比较不同分型的预后情况.结果:ALL-L1、ALL-L2与ALL-L3的首次诱导CR率(X2=1.087,P＞0.05)、完全CR率(X2=0.607,P＞0.05),差异无统计学意义；CR的治疗时间(t=6.001,P＜0.05)、3年生存率(X2=9.458,P＜0.05),差异有统计学意义.T-ALL、B-ALL的首次诱导CR率(X2=8.891,P＜0.05)、达到CR治疗时间(t=6.361,P＜0.05)、完全CR率(X2=11.892,P＜0.05),差异有统计学意义.两型的3年生存率(X2=1.536,P＞0.05),差异有统计学意义.B-ALL中各型别首次诱导CR率(X2=0.494,P＞0.05)和完全CR率(X2=0.405,P＞0.05),差异统计学意义.B-ALL中各型别达到CR的治疗时间(t=7.007,P＜0.05)和3年生存率(X2=6.609,P＜0.05),差异有统计学意义.结论:儿童急性白血病其预后与其分型有一定的相关性,因此临床治疗应结合患儿的分型进行个体化治疗.

The Prognostic of Acute Lymphoblastic leukemia Affecting by Somatotype

Objective: To analysis the somatotype of acute lymphoblastic leukemia influenced the prognostic,in order to provide basis for clinical treatment.Methods: A retrospective analysis of the clinical data for 36 patients with acute lymphoblastic leukemia in our hospital Jan.2007 to Dec.2010,to compare the prognostic.Results: The rate of first guide CR(X2=1.087,P>0.05)and the rate of CR(X2=0.607,P>0.05)of ALL-L1、ALL-L2 and ALL-L3 weren’t statistical different significantly.The time of reached CR(t=6.001,P<0.05)and the rate of 3-year-survied(X2=9.458,P<0.05)of ALL-L1,ALL-L2 and ALL-L3 were statistical different significantly.The rate of first guide CR(X2=8.891,P<0.05),The time of reached CR(t=6.361,P<0.05),the rate of CR(X2=11.892,P<0.05)of T-ALL,B-ALL were statistical different significantly.The rate of 3-year-survied(X2=1.536,P>0.05)wasn’t statistical different significantly.The rate of first guide CR(X2=0.494,P>0.05)and the rate of CR(X2=0.405,P>0.05)of the three of B-ALL weren’t statistical different significantly.The time of reached CR(t=7.007,P<0.05)and the rate of 3-year-survied(X2=6.609,P<0.05)were statistical different significantly.Conclusion: The prognostic of ALL and the somatotype have relationship,so ALL were crued with individual factors for children.