| 尼美舒利的临床应用及其不良反应 |
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| 引用本文： | 金星,崔红花,陶曙红,尹永芹.尼美舒利的临床应用及其不良反应[J].现代生物医学进展,2012,12(25):4995-4997. |
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| 作者姓名： | 金星 崔红花 陶曙红 尹永芹 |
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| 作者单位： | 黑龙江省食品药品检验检测所;广东药学院中药化学与分析系 |
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| 基金项目： | 广东省建设中医药强省科研课题(2009248) |
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| 摘 要： | 尼美舒利具有强大的抗炎、镇痛和解热作用。临床主要用于急慢性疼痛、关节炎、月经痛、癌症疼痛和解热。其作用机理主要是通过选择性抑制COX-2而抑制前列腺素的合成。尼美舒利的不良反应与其他NSAIDs相似,但对胃肠道副作用较少。本文总结了尼美舒利的主要临床应用及不良反应。
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| 关 键 词： | 尼美舒利 非类固醇抗感染药物 临床应用 不良反应 |
Clinical Applications of Nimesulide and its Adverse Reactions |
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| JIN Xing,CUI Hong-hu,TAO Shu-hong,YIN Yong-qin.Clinical Applications of Nimesulide and its Adverse Reactions[J].Progress in Modern Biomedicine,2012,12(25):4995-4997. |
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| Authors: | JIN Xing CUI Hong-hu TAO Shu-hong YIN Yong-qin |
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| Institution: | 1 Heilongjiang Institute for Food and Drug Control,Harbin,Heilongjiang,150001,China; 2 Department of Chemistry and Analysis of Traditional Chinese Medicine,Guangdong College of Pharmacy,Guangzhou,Guangdong,510006,China) |
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| Abstract: | Nimesulide has strong anti-inflammatory,analgesic and antipyretic effects.Clinically,it is the principal treatment in various acute and chronic pain conditions,joint infiammation in osteoarthritis,dysmenorrhoea,cancer pain,and anti-pyretic.Its mode of action in these states is related to the preferential inhibition of the production of cyclo-oxygenase-2(COX-2).The adverse reaction profile of nimesulide is like that of other NSAIDs.However,Nimesulide has a relatively low incidence of gastrointestinal(GI) side effects.This review summarized the principal clinical applications and adverse reaction of nimesulide. |
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| Keywords: | Nimesulide NSAIDs Clinical applications Adverse side reaction |
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