| MiR-203 及其调控机制的研究进展 |
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| 引用本文： | 王健,邹仲敏,赵吉清.MiR-203 及其调控机制的研究进展[J].现代生物医学进展,2012,12(14):2743-2747. |
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| 作者姓名： | 王健 邹仲敏 赵吉清 |
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| 作者单位： | 第三军医大学军事预防医学院毒理学研究所 重庆400038 |
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| 基金项目： | 国家自然科学基金面上项目(31171118) |
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| 摘 要： | MicroRNA(miRNA)是一种长18-25个碱基的单链非编码RNA,其广泛参与机体众多病理、生理过程。MiR-203是一种上皮组织特异性表达的miRNA。研究发现miR-203在皮肤发育、皮肤相关疾病、上皮组织肿瘤等病理、生理过程中发挥重要调控作用。一些疾病的研究还发现了miR-203与表观遗传学机制的相互作用,而miR-203调控机制的研究集中在P63、SOCS-3及相关的信号通路等方面。
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| 关 键 词： | MiR-203 调控 皮肤 |
The Research Progress of MiR-203 and its Regulation Mechanisms |
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| WANG Jian,ZOU Zhong-min,ZHAO Ji-qing.The Research Progress of MiR-203 and its Regulation Mechanisms[J].Progress in Modern Biomedicine,2012,12(14):2743-2747. |
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| Authors: | WANG Jian ZOU Zhong-min ZHAO Ji-qing |
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| Institution: | (Institute of toxicology,Preventive medical college,Third military medical Universty,Chongqing 400038) |
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| Abstract: | MicroRNAs(miRNA) are 18-25-nucleotide,single-stranded,non-coding RNAs that participate in many pathological and physiological processes of the body.MiR-203 is a miRNA specially expressed in epithelial tissue.Researches show that miR-203 plays an important role in skin development,skin-related diseases,epithelial tumors and other pathological and physiological processes.The interaction between miR-203 and epigenetic mechanisms is also discovered in the researches on some diseases,while the researches on the regulation mechanisms of miR-203 focus on P63,SOCS-3 and related signal pathways. |
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| Keywords: | MiR-203 Regulation Skin |
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