VEGF 对大鼠脑缺血再灌注损伤的预防作用及其机制研究

目的:观察复方甘草酸苷联合抗组胺类药物治疗慢性荨麻疹的临床疗效.方法:150例慢性荨麻疹患者随机分为治疗组和对照组,治疗组口服复方甘草酸苷片和西替利嗪片,对照组只给予西替利嗪片,疗程14d.评价1周和2周时的荨麻疹活动度评分表和临床疗效.结果:治疗1周末和2周末两组的荨麻疹活动度评分都明显下降,与治疗前比较差异具有统计学意义(P＜0.05),两组1周末和2周末时比较差异具有统计学意义(P＜0.05).1周末两组总有效率分别为64.0％和38.7％,差异具有统计学意义(P＜0.05)；2周末总有效率分别为90.7％和61.3％,差异具有统计学意义(P＜0.05).结论:复方甘草酸苷联合西替利嗪片治疗慢性荨麻疹具有起效快、疗效高的特点.

The Effect of Compound Glycyrrhizin Combined with Antihistamines on Chronic Urticaria

Objective: To evaluate the effect of compound glycyrrhizin combined with antihistamines on chronic urticaria.Methods: 150 cases with chronic urticaria were randomly divided into treatment group and control group.The treatment group was given compound glycyrrhizin combined with cetirizine,while the control group was treated with cetirizine only.After 14 days,the urticaria activity score(UAS) and efficacy were evaluated by the end of one and two weeks.Results: The UAS in the both groups were lowered significantly after one and two weeks’ treatment(P<0.05),and the two groups also showed significant difference by the end of one and two weeks(P<0.05).The total effective rate in the two groups at one week were 64.0% and 38.7%,respectively(P<0.05);And also at two weeks the total effective rate in treatment group was higher than that of control group(90.7% vs 61.3%,P<0.05).Conclusions: Compound glycyrrhizin combined with antihistamines is an effective therapy for chronic urticaria,with rapid and high efficacy.