叶酸对心脑血管疾病二级预防作用的研究

目的:探讨叶酸对心脑血管疾病二级预防的效果。方法:326例恢复期心脑血管疾病患者以自愿的原则分为实验组(n=201)和对照组(n=125),对照组针对病因应用常规药物,实验组在针对病因常规用药的基础上应用叶酸,随访三年,所有患者均在实验前和半年后测一次血清同型半胱氨酸含量,同时记录对比两组心脑血管不良事件的发生率。结果:323例纳入统计,实验组和对照组在入选时同型半胱氨酸含量无差异(P>0.05),半年后实验组血清同型半胱氨酸含量显著低于对照组(P<0.05);心绞痛、心力衰竭、血栓形成等发生率差异均具有统计学意义(均为P<0.05),而在心肌梗死、脑梗死和病死率等方面差异没有统计学意义(P>0.05)。结论:叶酸在心脑血管疾病二级预防中可以降低心绞痛发生率、心力衰竭、血栓形成的发生率,对心肌梗死、脑梗死和病死率没有明显的影响。

Research on the Secondary Prevention of Folic Acid on Cardiovascular and Cerebrovascular Diseases

Objective: To explore the Secondary prevention effectiveness of folic acid on Cardiovascular and cerebrovascular diseases.Methods: There are 326 patients with Cardiovascular and cerebrovascular diseases were divided into the experimertal group(n=201) and the control group(n=125) by voluntary principle,the experimertal group treated with common treatment and folic acid and the control group only treated with common treatment.follow-up visit for 3 year,serum homocysteine(Hcy) of experimertal group and the control group was Detected before and after six months ’ test.cardiovascular and cerebrovascular events were recorded and compared in the two groups simultaneously.Results: 323 cases adopted and statisticed,there was no statistical significance of serum homocysteine(Hcy) level(P>0.05)between the two groups before test,there was significant difference(P < 0.05) between the two groups in serum homocysteine(Hcy) level.The incidence of angina,heart failure and thrombosis in the two groups had significant differences(p <0.05).The incidence of myocardial infarction,cerebral infarctio and mortality in the two groups had no statistical significance(P>0.05).Conclusion: Folic acid can reduce the incidence of angina,heart failure and thrombosis,It had no effect on incidence of myocardial infarction,cerebral infarctio and mortality in Secondary prevention of Cardiovascular and cerebrovascular diseases.