| 银杏内酯B 诱导大鼠骨髓间充质细胞分化为神经元样细胞的电生理研究 |
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| 引用本文： | 陆燕,刘沙,刘的,刘欣,刘德全,刘永海.银杏内酯B 诱导大鼠骨髓间充质细胞分化为神经元样细胞的电生理研究[J].现代生物医学进展,2012,12(15):2826-2828. |
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| 作者姓名： | 陆燕 刘沙 刘的 刘欣 刘德全 刘永海 |
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| 作者单位： | 1. 徐州医学院附属医院神经内科徐州医学院神经病学教研室 江苏徐州221000
2. 南京医科大学第一附属医院神经内科 江苏南京210029 |
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| 摘 要： | 目的:研究银杏内酯B(GB)诱导大鼠骨髓间充质细胞(MSCs)分化为神经元样细胞的电生理特性。方法:应用膜片钳技术,采用全细胞记录方式,对由GB诱导的大鼠MSCs进行诱导前后的电生理功能测定。结果:分化后的神经元样细胞较诱导前细胞的膜特性有了显著改变(P<0.05)。结论:大鼠MSCs经过GB诱导能够向功能性神经元方向分化。
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| 关 键 词： | 骨髓间充质细胞 银杏内酯B 全细胞膜片钳 神经元样细胞 |
Electrophysiology Study on Differentiation of Rat Bone Marrow Stromal
Stem Cells into Neurom-like Cells by Ginkgolide B |
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| LU Yan,LIU Sh,LIU Di,LIU Xin,LIU De-quan,LIU Yong-hai.Electrophysiology Study on Differentiation of Rat Bone Marrow Stromal
Stem Cells into Neurom-like Cells by Ginkgolide B[J].Progress in Modern Biomedicine,2012,12(15):2826-2828. |
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| Authors: | LU Yan LIU Sh LIU Di LIU Xin LIU De-quan LIU Yong-hai |
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| Institution: | 1(1 Department of Neurology,the Affiliated Hospital of Xuzhou Medical University,Department of Neurology of Xuzhou Medical University,Xuzhou 221000,China; 2 Department of Neurology,the First Affiliated Hospital to Nanjing Medical University,Nanjing 210029,China) |
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| Abstract: | Objective: To investigate the elctrophysiological properties of differentiation of rat bone marrow stroma cell(MSCs) induced by Ginkgolide B(GB).Methods: Elctrophysiologica functions of rat MSCs before and after differentiating into neurons-like cells were induced by GB.Results: The membrance properties changed a lot between differerntiated cell and undifferentiated neuron-like cell(P<0.05).Conclusion: MSCs can differentiate into functional neurons if induced by GB. |
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| Keywords: | Marrow stroma cell Ginkgolide B Whole cell patch clamp Neuron-like cell |
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