三维适形放疗技术的治疗原发性肝癌的影响因素分析

目的:探讨影响三维适形放疗(3-Dimensional conformal radiotherapy,3DCRT)治疗原发性肝癌的影响因素.方法:收集2008年1月到2010年12月间58例我院原发性肝癌病人,先通过CT扫描定位勾画靶区,经实时验证参数后实施适形放射治疗.观察疗效.并运用Cox回归模型对肿瘤大小、肿瘤分期、肝功能和甲胎蛋白(AFP)水平和照射剂量因素进行分析.结果:完全缓解(CR)13例,部分缓解(PR)35例,总有效(CR+PR)率为82.76％,1、2、3年生存率分别为69.5％、43.10％、27.57％.肿瘤大小、肿瘤分期、甲胎蛋白水平和照射剂量可影响3DCRT效果(P小于0.05),肝功能对3DCRT效果(P小于0.05).结论:肿瘤分期、肝功能和甲胎蛋白(AFT)水平,分割方式、照射剂量和效应可影响三维适形放疗治疗原发性肝癌的效果.

Image Factors of the Three-Dimensional Conformal Radiotherapy

Objective: To investigate the impact of three-dimensional conformal radiotherapy(3-Dimensional conformal radiotherapy with 3DCRT) treatment of primary liver cancer influencing factors.Methods: 58 cases of hospital patients with primary liver cancer in January 2008 to December 2010,the first CT scan positioning outlined target,the implementation of conformal radiation therapy after real-time authentication parameters.Effects were observed.And the use of Cox regression model on the tumor size,tumor stage,liver function and alpha-fetoprotein(AFP) levels and radiation dose factors were analyzed.Results: Complete remission(CR) 13 cases,partial remission(PR),35 cases,the total effective(CR+PR) rate was 82.76%,1-,2-and 3-year survival rates were 69.5%,43.10%,27.57%.Tumor size,tumor stage,alpha-fetoprotein levels and radiation dose can affect the the 3DCRT effect(P less than 0.05),liver function,the the 3DCRT effect(P less than 0.05).Conclusion: Tumor stage,the level of liver function and alpha-fetoprotein(AFT),partitioned,radiation dose and effects may influence the effect of three-dimensional conformal radiation therapy for primary liver cancer.