帕金森病抑郁的相关因素分析

目的:探讨抑郁在帕金森病中(Parkinson’s disease,PD)的发生率及其影响因素。方法:对确诊的PD患者,采用汉密尔顿抑郁量表(Hamilt depression scale,HAMD)、简易精神状态检查量表(Mini-Mental State Examination,MMSE)及Webster功能评分量表进行评定,分析抑郁的发生情况和相关影响因素。结果:PD伴发抑郁者32例,抑郁的发生率为49.2%,病程、文化程度、Webster评分、MMSE评分与帕金森抑郁的发生均有统计学意义(P<0.05),年龄、性别、婚姻状况、经济情况与帕金森抑郁的发生均无统计学意义(P>0.05)。回归分析发现病程和病情严重程度是PD患者抑郁的危险因素。结论:PD患者有较高的抑郁发生率,抑郁的发生可能是社会心理、神经生物学多种因素作用的结果。

A Study of Related Factors of Depression in Parkinson Disease

Objective: To investigate the prevalence of depression in patients with Parkinson’s disease and its correlated factors.Methods: For the diagnosed PD patients,evaluated with the Hamilton Depression Rating Scale(HAMD),the mini-mental state examination(MMSE) and the Webster rating scale,analysis of the incidence of depression and related factors.Results: 32 PD patients were associated with depression,and the frequency of depression was 49.2%.There were significant differences in duration of disease,educational level,webster score and MMSE score(P<0.05).There were no statistical relationships between age,gender,marital status and economic situation(P>0.05).Logistic regression analysis demonstrated that the most important predictive factors for depression were duration of disease and severity of disease.Conclusion: The prevalence of depression was high in PD patients,and may be occur for social psychology,neurobiology result of many factors.