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Kynurenic acid amides as novel NR2B selective NMDA receptor antagonists |
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| Authors: | Borza István Kolok Sándor Galgóczy Kornél Gere Anikó Horváth Csilla Farkas Sándor Greiner István Domány György |
| Affiliation: | Gedeon Richter Ltd, Budapest 10, PO Box 27, H-1475, Hungary. i.borza@richter.hu |
| Abstract: | A novel series of kynurenic acid amides, ring-enlarged derivatives of indole-2-carboxamides, was prepared and identified as in vivo active NR2B subtype selective NMDA receptor antagonists. The synthesis and SAR studies are discussed. |
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