Systems biology by the rules: hybrid intelligent systems for pathway modeling and discovery |
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Authors: | William J Bosl |
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Institution: | (1) Harvard Medical School and Children's Hospital Informatics Program at Harvard-MIT Division of Health Sciences and Technology (ChIP@HST), Boston, MA 02115, USA |
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Abstract: | Background Expert knowledge in journal articles is an important source of data for reconstructing biological pathways and creating new
hypotheses. An important need for medical research is to integrate this data with high throughput sources to build useful
models that span several scales. Researchers traditionally use mental models of pathways to integrate information and development
new hypotheses. Unfortunately, the amount of information is often overwhelming and these are inadequate for predicting the
dynamic response of complex pathways. Hierarchical computational models that allow exploration of semi-quantitative dynamics
are useful systems biology tools for theoreticians, experimentalists and clinicians and may provide a means for cross-communication. |
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Keywords: | |
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