The inhibitory effect of BSP-A1/-A2 on protein kinase C and tyrosine protein kinase |
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Authors: | Yu Bingzhi Zhao Yongmei Zhao Wei Chen Fei Liu Ying Zhang Jie Fu Wei Zong Zhihong Yu Aiming Guan Yi |
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Institution: | Department of Biochemistry, China Medical University, 92, North Second Road, Shenyang, Liaoning Province, 110001, People's Republic of China. ybingzhi@yeah.net |
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Abstract: | Bovine seminal plasma contains a group of similar proteins, namely BSP-A1, BSP-A2, BSP-A3, and BSP-30-kDa (collectively called BSP proteins), and they are secreted by the seminal vesicles. In our study, we purified the BSP-A1/-A2 through affinity chromatography and found for the first time that BSP-A1/-A2 can inhibit the activity of protein kinase C (PKC) and tyrosine protein kinase (TPK). The inhibition was dose dependent. When the PKC and TPK activities are expressed as the logarithm of percentage activity taking the activity in the absence of the BSP-A1/-A2 as 100%, there is a linear relationship between the their activities and the dose of BSP-A1/-A2. |
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Keywords: | protein kinase C tyrosine protein kinase BSP‐A1/‐A2 inhibition |
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