125I和65Zn在大蟾蜍体内的吸收与分布

利用同位素示踪法研究了不同引入途径的125I和65Zn在大蟾蜍体内的吸收与分布。无论采用注射还是灌喂的方法,蟾蜍对125I的残留动态差别不大,都可分为快清除期和平台期,0～2d为快清除期,3～7d为平台期,经过了快清除期之后,残留的125I约为起始量的8%,并维持到实验结束。注射了65Zn后,0～7d的吸收动态曲线有所起伏,但波动很小,其波动范围为102.4%～114.48%。表明大部分的65Zn仍留在体内,几乎没有排出体外。注射65Zn的转移并不明显。但灌喂65Zn的动态变化则大些,而且转移明显。其活度曲线出现阶段性下降,有两个下降期,第一个下降期为4h～3d,第二个下降期为5～7d。说明灌喂组对65Zn的转移比注射组的活跃,但在实验的第7d残留率仍在60%以上。

Uptake and Distribution of 125I and 65Zn in Toad Bufo bufo

The uptake and distribution of 125I and 65Zn in toad Bufo bufo by different ways were studied.Results showed that the retention dynamics of 125I in toad,whether injection or oral administration,had little differences.Both of them composed of a quick elimination stage and followed by a platform stage.During the quick elimination stage(0-2d),the radioactivity decreased significantly.Then the retention rate of 125I in toad was maintained about 8% during the following experiment.After injected with 65Zn,the retention rate was between 102.4%-114.48%,implying that almost all of 65Zn remained in the body,the loss of Zn was not significantly.However,by oral administration,the retention dynamics of 65Zn was significantly different from the injection group.The retention rate decreased slowly during the experiment.