| 结核分枝杆菌对宿主巨噬细胞死亡方式的调控 |
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| 引用本文： | 杨瑞丽,孙佳楠,陆伟. 结核分枝杆菌对宿主巨噬细胞死亡方式的调控[J]. 生命科学, 2013, 0(11): 1084-1088 |
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| 作者姓名： | 杨瑞丽 孙佳楠 陆伟 |
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| 作者单位： | [1]东南大学病原生物学与免疫学系,南京210009 [2]江苏省疾病预防控制中心,南京210009 |
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| 基金项目： | 江苏省卫生厅重点实验室开放项目（WKF-2013-05） |
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| 摘 要： | 结核分枝杆菌（Mycobacterium tuberculosis，Mtb）感染后能抑制宿主巨噬细胞（M西）的免疫反应，并在其中生存、复制。研究表明Mtb减毒株感染主要诱导宿主Mφ凋亡，凋亡能抑制胞内Mtb的活力；而Mtb毒力株感染能抑制凋亡的完成，诱导Mφ坏死，最终导致Mtb扩散、感染临近细胞。通过对Mtb感染诱导宿主Mφ不同死亡方式的讨论，进一步认识Mtb的致病机制。
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| 关 键 词： | 结核分枝杆菌 巨噬细胞 凋亡 坏死 毒力 |
The death of host macrophages regulated by Mycobacterium tuberculosis |
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| YANG Rui-Li,SUN Jia-Nan,LU Wei. The death of host macrophages regulated by Mycobacterium tuberculosis[J]. Chinese Bulletin of Life Sciences, 2013, 0(11): 1084-1088 |
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| Authors: | YANG Rui-Li SUN Jia-Nan LU Wei |
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| Affiliation: | 1 Department of Pathogenic Biology and Immunology, School of Medicine, Southeast University, Nanjing 210009, China; 2 Department of Chronic Infectious Diseases, Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210009, China) |
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| Abstract: | Mycobacterium tuberculosis （Mtb） can suppress host macrophage （Mφ） immune defenses, and use host Mφ resources for survival and replication. Attenuated strains of Mycobacteria induce more apoptosis than their virulent counterparts Mtb, which diminish pathogen viability. However, virulent Mtb strains inhibit the completion of apoptosis and foil host defenses, which results in necrosis of macrophages, and then the exit of bacteria from the macrophage and spread. This paper intends to further introduce the pathogenesis of Mtb through the discussion of the different death modalities of host Mφ infected with Mtb. |
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| Keywords: | Mycobacterium tuberculosis macrophages apoptosis necrosis virulence |
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