Changes in mitochondrial proteins during neuroblastoma differentiation |
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| Authors: | J L Vayssière F Berthelot B Croizat F Gros |
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| Affiliation: | Laboratoire de Biochimie Cellulaire, Collège de France, 11, Place Marcelin Berthelot, 75231 Paris Cedex 05, France |
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| Abstract: | The evolution of three major mit-proteins was followed in neuroblastoma cells cultured in different conditions of differentiation. 1 methyl cyclohexane carboxylic acid (CCA) was found to stimulate the synthesis of the three mit-protein markers. This result, compared to the effects of oligomycin, an inhibitor of mitochondrial function, favours the hypothesis that CCA induces in vitro neurogenesis through a general metabolic alteration. |
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| Keywords: | mit-protein mitochondrial protein mitpro precursor of mitochondrial protein |
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