A 型肉毒毒素治疗半侧面肌痉挛的临床疗效评价

目的：观察A型肉毒毒素对面肌痉挛患者的痉挛程度、抑郁症状和焦虑症状的改善。方法：对58例面肌痉挛患者进行局部注射A型肉毒毒素。在治疗前后对痉挛程度改善情况进行评定以及用汉密顿焦虑量表（HAMA）、汉密顿抑郁量表（HAMD）对焦虑状态、抑郁状态进行评分，并对药物的副作用进行观察。结果：A型肉毒毒素明显改善面肌痉挛患者的痉挛程度，治疗后2周的HAMA、HA肋评分较治疗前明显下降，且差异具有统计学意义（P〈0．01）。结论：局部注射A型肉毒毒素可迅速缓解或消除面肌痉挛患者肌肉痉挛及相关的抑郁和焦虑状态，提高患者的生活质量。

Clinical Analysis of Botulinus Toxin A for Hemifacial Spasm

Objective: To observe the effect of Botulinum Toxin A(BTA) on the hemifacial spasm(HFS) patients with spasm,anxiety and depression symptoms.Methods: 58 patients with hemifacial spasm were treated with BTA.The degree of spasm alleviations and the HAMA and HAMD of patients were assessed before and after treatment.Results: BTA can alleviate the spasm of all the patients.Two weeks after treatment,the grades of HAMA and HAMD greatly decreased with statistic significance(P<0.01).Conclusion: BTA injected locally can relieve the patients with HFS from spasm,anxiety and depression,and improve their living quality.