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Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells |
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| Authors: | Ke Wei Gong Wei Zhao Ning Li Berenice Barajas Michael Kleinman Constantinos Sioutas Steve Horvath Aldons J Lusis Andre Nel Jesus A Araujo |
| Affiliation: | (1) Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA;(2) Departments of Human Genetics and Biostatistics, University of California, Los Angeles, CA 90095, USA;(3) Department of Community and Environmental Medicine, University of California, Irvine, CA 92697, USA;(4) Department of Civil and Environmental Engineering, University of Southern California, Los Angeles, CA 90089, USA |
| Abstract: | BackgroundAmbient air pollution is associated with increased cardiovascular morbidity and mortality. We have found that exposure to ambient ultrafine particulate matter, highly enriched in redox cycling organic chemicals, promotes atherosclerosis in mice. We hypothesize that these pro-oxidative chemicals could synergize with oxidized lipid components generated in low-density lipoprotein particles to enhance vascular inflammation and atherosclerosis. |
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