Cornel Iridoid Glycoside Inhibits Inflammation and Apoptosis in Brains of Rats with Focal Cerebral Ischemia |
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Authors: | Bai-liu Ya Chun-yang Li Lan Zhang Wen Wang Lin Li |
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Institution: | (1) Department of Pharmacology, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Xuanwu Hospital of Capital Medical University, 45 Chang-chun Street, 100053 Beijing, People’s Republic of China;(2) Department of Neurology, Affiliated Hospital of Inner Mongolia Medical College, 010059 Hohhot, Inner Mongolia, People’s Republic of China; |
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Abstract: | The capacity of cornel iridoid glycoside (CIG) to suppress the manifestations of ischemic stroke was investigated. CIG was
administered to rats by the intragastric route once daily for 7 days. Focal cerebral ischemia was induced by 2 h of middle
cerebral artery occlusion followed by 24 h of reperfusion. In non-treated rats large infarct areas were observed within 24 h
of reperfusion. Examination of the ischemic cerebral cortex revealed microglia and astrocyte activation, increased interleukin-1β
(IL-1 β) and tumor necrosis factor-α (TNF-α) concentrations, increased DNA fragmentation in the ischemia penumbra, elevated
Bax expression, increased caspase-3 cleavage, and decreased Bcl-2 expression. Pretreatment with CIG decreased the infarct
area, DNA fragmentation, IL-1β and TNF-α concentrations, microglia and astrocyte activation, Bax expression, and caspase-3
cleavage while increasing Bcl-2 expression. CIG exerts anti-neuroinflammatory and anti-apoptotic effects which should prove
beneficial for prevention or treatment of stroke. |
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