副溶血性弧菌生物被膜形成及其调控机制研究进展

副溶血性弧菌是一种广泛存在于海产品中并可引起人类急性肠胃炎的食源性致病菌。该菌形成的生物被膜能够增强体外环境中的存活率，促进对宿主的定殖和感染，还会导致被污染的加工设备与食物之间发生交叉感染。深入了解生物被膜形成背后的调控机制，有助于制定有针对性的策略，干扰其适应环境变化的过程，从而降低副溶血性弧菌对人类的危害。本文主要综述了鞭毛、菌毛和胞外的多糖等基质组分在生物被膜形成中的作用以及c-di-GMP和群体感应对生物被膜形成的调控。

Biofilm formation and regulation mechanism of Vibrio parahaemolyticus: progress and trends

Vibrio parahaemolyticus, the causative agent of seafood-borne acute gastroenteritis worldwide, benefits from a sessile biofilm lifestyle that enhances survival outside the host, contributes to host colonization and infectivity but also leads to cross-contamination between processing equipment and foods. Insight into the regulatory circuit underlying biofilm formation may propose targeted strategies to interfere with a process that renders this bacterium remarkably adaptable to changing environments. Here, we mainly demonstrated the regulatory of two mobility structures (flagella, pili), extracellular matrix polysaccharides, the second messenger c-di-GMP and quorum-sensing system that contribute to biofilm formation.