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Antitumor agents. Part 214: synthesis and evaluation of curcumin analogues as cytotoxic agents |
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| Authors: | Ishida Junko Ohtsu Hironori Tachibana Yoko Nakanishi Yuka Bastow Kenneth F Nagai Masahiro Wang Hui-Kang Itokawa Hideji Lee Kuo-Hsiung |
| Affiliation: | Hoshi University, 2-4-41 Ebara, Shinagawa, Tokyo, Japan. |
| Abstract: |  Fifty-eight curcumin analogues were prepared and evaluated for in vitro cytotoxicity against a panel of human tumor cell lines. Compound was the most potent analogue against several cell lines, including HOS (bone cancer) and 1A9 (breast cancer), with ED50 values of 0.97 and <0.63 microg/mL, respectively. |
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| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |