川崎病患儿肠道菌群构成及分布与其冠状动脉病变的相关性分析

摘要 目的：分析川崎病患儿肠道菌群构成及分布与其冠状动脉病变的相关性。方法：选择我院自2020年1月至2023年2月接诊的86例川崎病患儿作为研究对象，根据是否出现冠状动脉病变，分为冠状动脉病变组（35例）和非冠状动脉病变组（51例）。检测所有患儿的肠道菌群多样性肠道菌群丰度（Ace指数）、肠道菌群多样性（Shannon指数）]、肠道菌群构成比例门水平（变形菌门、厚壁菌门、拟杆菌门）、属水平（乳杆菌属、拟杆菌属、韦荣球菌属）]，使用多因素Logistic回归分析肠道菌群构成及分布与冠状动脉病变的关系。结果：冠状动脉病变组Ace指数大于非冠状动脉病变组（P＜0.05）；冠状动脉病变组与非冠状动脉病变组的Shannon指数比较无差异（P＞0.05）；冠状动脉病变组肠道厚壁菌门占比低于非冠状动脉病变组，拟杆菌门占比高于非冠状动脉病变组（P＜0.05）；冠状动脉病变组与非冠状动脉病变组的肠道变形菌门占比比较无差异（P＞0.05）；冠状动脉病变组肠道乳杆菌属占比、韦荣球菌属占比均低于非冠状动脉病变组（P＜0.05）；冠状动脉病变组与非冠状动脉病变组的肠道拟杆菌属占比比较无差异（P＞0.05）；经多因素Logistic回归分析，肠道Ace指数、厚壁菌门、拟杆菌门、乳杆菌属、韦荣球菌属均是川崎病患儿发生冠状动脉病变的独立影响因素（P＜0.05）。结论：川崎病患儿肠道菌群构成及分布与其冠状动脉病变密切相关，为改善肠道菌群失调、增加患儿的临床获益提供依据，应引起临床重视。

Correlation Analysis of Intestinal Flora Composition and Distribution with Coronary Artery Disease in Children with Kawasaki Disease

ABSTRACT Objective: To analyze the correlation between intestinal flora composition and distribution and coronary artery disease in children with Kawasaki disease. Methods: A total of 86 children with Kawasaki disease treated in our hospital from January 2020 to February 2023 were selected as research objects.According to the occurrence of coronary artery disease, they were divided into coronary artery disease group (35 cases) and non-coronary artery disease group (51 cases). Intestinal flora diversity intestinal flora abundance (Ace index), intestinal flora diversity (Shannon index)], intestinal flora composition ratio phylum level (Proteobacteria, Firmicutes,Bacteroides), and genus level (Lactobacillus, Bacteroides, Veronococcus) of all children were detected. Multivariate Logistic regression was used to analyze the relationship between intestinal flora composition and distribution and coronary artery disease. Results: The Ace index of coronary artery disease group was higher than that of non-coronary artery disease group (P<0.05). There was no significant difference in Shannon index between the coronary disease group and the non-coronary disease group (P>0.05). The proportion of firmicutes in the coronary artery disease group was lower than that in the non-coronary artery disease group, and the proportion of Bacteroidetes was higher than that in the non-coronary artery disease group (P<0.05). There was no difference in the proportion of intestinal proteobacteria between the coronary artery disease group and the non-coronary artery disease group (P>0.05). The proportion of Lactobacillus and Veillonococcus in intestinal tract in coronary artery disease group was lower than that in non-coronary artery disease group (P<0.05). There was no significant difference in the proportion of Bacteroides in the coronary and non-coronary groups (P>0.05). Multiple Logistic regression analysis showed that intestinal Ace index, Firmicutes, Bacteroidetes, Lactobacillus and Veronococcus were all independent factors influencing the occurrence of coronary artery lesions in children with Kawasaki disease (P<0.05). Conclusion: The composition and distribution of intestinal flora in children with Kawasaki disease are closely related to coronary artery disease, which provides evidence for improving intestinal flora disorder and increasing clinical benefit of children.