Influence of aluminum tristearate and sucrose stearate as the dispersing agents on physical properties and release characteristics of Eudragit RS microspheres |
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Authors: | B Bahar Horoz Müge Kiliçarslan Nilüfer Yüksel Tamer Baykara |
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Institution: | (1) Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara University, 06100 Tandoĝan-Ankara, Turkey |
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Abstract: | The purpose of this research was to investigate the effects of different concentrations of polymer and sucrose stearate, aluminum
tristearate as dispersing agents on microsphere properties and performance. The yield values of microspheres were over the
78%, and the encapsulation efficiencies were found to be ∼735. Particle sizes of microspheres prepared with aluminum tristearate
were between 76 and 448 μm, while that of the microspheres containing sucrose stearate were between 521 and 2000 μm. Morphological
and physicochemical properties of microspheres were investigated by scanning electron micrography and differential scanning
calorimetry (DSC). DSC analysis indicated that verapamil hydrochloride formed a solid solution with acrylic polymers. In vitro
release studies were performed using the flow-through cell method. While ∼80% of drug was released from the microspheres containing
aluminum tristearate in 480 minutes, the same amount of drug was released from microspheres containing sucrose stearate in
only 60 minutes. Chemical structures and concentrations of the dispersing agents were clearly effective on the physical properties
of microspheres and their drug-release characteristics.
Published: February 24, 2006 |
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Keywords: | aluminum tristearate sucrose stearate Eudragit RS 100 solvent evaporation method verapamil HCl |
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