Polymorphism,genetic exchange and intragenic recombination of the aureolysin gene among Staphylococcus aureusstrains |
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| Authors: | Artur J Sabat Benedykt Wladyka Klaudia Kosowska-Shick Hajo Grundmann Jan Maarten van Dijl Julia Kowal Peter C Appelbaum Adam Dubin Waleria Hryniewicz |
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| Affiliation: | (1) National Medicines Institute, 00-725 Warsaw, Poland;(2) Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Cracow, Poland;(3) Department of Pathology, Hershey Medical Center, P.O. Box 850, 17033 Hershey, PA, USA;(4) RijksInstituut voor Volksgezondheid en Milieu (RIVM), Bilthoven, The Netherlands;(5) Department of Medical Microbiology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands |
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| Abstract: | Background
Staphylococcus aureus expresses several proteases, which are thought to contribute to the virulence of this bacterium. Here we focus on aureolysin,
the major thermolysin-like metalloprotease. Despite the importance of aureolysin in the physiology and pathogenesis of S. aureus, relatively little information was so far available concerning the aur gene diversity and mobility within and between the major subdivisions of the S. aureus population. Therefore, an epidemiologically and genetically diverse collection of S. aureus strains was used to determine the range of aureolysin (aur) gene polymorphism. |
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