大鼠肝癌诱发过程中血粘度及红细胞变形能力的异常改变

为了全面地反映肝癌发生发展整个过程的血液流变性的异常，本实验采用二乙基亚硝胺诱发大鼠肝癌模型，分六个相检测五个切变率下的全血粘度、血浆粘度及红细胞变形能力。结果表明红细胞变形能力随着肿瘤发展逐渐减低，血浆粘度随着诱癌时间延长 渐升高，到肿瘤晚期趋于平缓，而全血粘度先是升高，到诱癌２０周以后反而有下降趋势。

Hemonileological Abnormality During The Diethylnitrosamine(DEN) Induced Rat Hepatocellular Carcinomas

In order to demonstrate the heroorrheological abnormality in the whole course of c&rcinogenesia, DEN - induced rat hepalocellular carcinoma model which is consistent with the concepts of intiation - promotion - progression as in rat was adopted. The whole blood viscosity in five shear rates, the plasma viscosity and the red cell deformability in different periods were measured. The results shows that red cell doformability was decreased during the whole carcinogenesis, the plasma viscosity was increaser as the time prolongation, but the tendency was lower in the late course. The whole blood viscosity was gotten its maximum in 20th week,and was descended in the late course of the camogenesis.