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The enhancement of radiosensitivity in human esophageal squamous cell carcinoma cells by zoledronic acid and its potential mechanism |
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| Authors: | Yanjie You Jianfeng Liu Zhizhong Wang Yuan Zhang Yonggang Ran Xu Guo Huimin Liu Haibo Wang |
| Institution: | 1. Department of Pharmacy, Luohe Medical College, 148 Daxue-Road, Luohe, 462002, China 2. Department of Cytobiology and Genetics, Ningxia Medical University, Yinchuan, 750004, China 3. Department of Neurosurgery, the First Hospital of Hebei Medical University, Shijiazhuang, 050000, China 4. Department of Statistic and Epidemiology, Ningxia Medical University, Yinchuan, 750004, China 5. Department of Teaching and Training, Bethune Military Medical NCO Academy of PLA, Shijiazhuang, 050081, China 6. Instrument Center, Bethune Military Medical NCO Academy of PLA, Shijiazhuang, 050081, China 7. Department of Physiology, Bethune Military Medical NCO Academy of PLA, Shijiazhuang, 050081, China |
| Abstract: | Esophageal squamous cell carcinoma (ESCC) has a low 5-year patient survival rate. Radiotherapy, as a preoperative or postoperative treatment of surgery, has a crucial role in improving local control and survival of ESCC. Various chemotherapeutic and biologic agents have been used as radio-sensitizers in combination with radiotherapy. Here, we demonstrate that zoledronic acid (ZOL) has a radio-sensitizing effect on ESCC cells. Exposure of ESCC cancer cells to ZOL plus radiation resulted in increased cell death through arresting the cell cycle between S and G2/M phases. ZOL appeared to inhibit proliferation, tube formation and invasion of endothelial cells. These anti-angiogenetic effects were more marked concurrently with irradiation. In addition, synergistic suppressive effects on VEGF expression were observed after combined treatment. Our data suggest that the combination of ZOL and radiation is a promising therapeutic strategy to enhance radiation therapy for ESCC patients. |
| Keywords: | ESCC Bisphosphonate Radiosensitivity Combined effect |
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