丝状真菌异源蛋白表达系统研究进展

丝状真菌，俗称霉菌，在食品工业中被用于生产多种生物酶和有机酸。近年来，人们发现丝状真菌具有分泌量大、表达的蛋白有天然活性等特点，非常适合作为同源和异源重组蛋白的表达宿主，因此被广泛研究和探讨。简要综述了以黑曲霉为代表的几种常被用作蛋白表达宿主的丝状真菌的特点、应用中的主要问题和基本解决方案，以及近年关于丝状真菌表达系统的最佳培养条件和发酵条件的研究进展。

Advances in Research of Heterologous Expression in Filamentous Fungi

The characteristic of producing the homologous and heterologous proteins in some convention spaces of filamentous fungi was reviewed. And the basic expression strategies, the putative problems and the putative solutions were introduced. In the end, the author reviewed recent progress in study of the effect of filamentous fungal morphology on heterologous protein secretion.