A retrovirus carrying the polyomavirus middle T gene induces acute thrombocythemic myeloproliferative disease in mice. |
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| Authors: | A Fusco G Portella M Grieco G Tajana G Di Minno N Polli and A Pinto |
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| Institution: | Centro di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Naples, Italy. |
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| Abstract: | Mice inoculated with an artificially constructed retrovirus carrying the middle T gene of polyomavirus develop acute myeloproliferative disease with severe thrombotic and hemorrhagic disorder and impaired platelet function. The megakaryocytic lineage appears to be a target for polyoma-murine leukemia virus infection and middle T gene expression. This newly described disease represents a unique model system for studying disorders of the megakaryocytic lineage. |
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