Cutting edge: CD4+ T cell control of CD8+ T cell reactivity to a model tumor antigen |
| |
Authors: | Surman D R Dudley M E Overwijk W W Restifo N P |
| |
Institution: | Surgery Branch, National Cancer Institute, Bethesda, MD 20892, USA. |
| |
Abstract: | Neoantigens resulting from the inherent genomic instability of tumor cells generally do not trigger immune recognition. Similarly, transfection of tumors with model Ags often fails to elicit CD8+ T cell responses or alter a tumor's growth rate or lethality. We report here that the adoptive transfer of activated Th1-type CD4+ T cells specific for a model tumor Ag results in the de novo generation of CD8+ T cells with specificity to that Ag and concomitant tumor destruction. The anti-tumor effects of the CD4+ T cells required the presence of both MHC class I and class II on host cells, as evidenced by experiments in knockout mice, suggesting that CD4+ T cells enhanced the ability of host APC to activate endogenous CD8+ T cells. These results indicate that the apparent inability of tumor cells expressing highly immunogenic epitopes to activate tumor-specific CD8+ T cells can be altered by activated CD4+ T cells. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|