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Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial |
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| Authors: | Ida C Helmark Ulla R Mikkelsen Jens Børglum Anders Rothe Marie CH Petersen Ove Andersen Henning Langberg Michael Kjaer |
| Affiliation: | 1.Institute of Sports Medicine, Department of Orthopaedic Surgery, Bispebjerg Hospital and Centre for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark;2.Department of Anaesthesiology and Intensive Care Medicine, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark;3.Clinical Research Centre and Dept. of Infectious Diseases, Hvidovre Hospital, Kettegård Allé 30, 2650 Hvidovre, Denmark |
| Abstract: | IntroductionThe microdialysis method was applied to the human knee joint with osteoarthritis (OA) in order to reveal changes in biochemical markers of cartilage and inflammation, intraarticularly and in the synovium, in response to a single bout of mechanical joint loading. |
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