Caffeine-induced enhancement of chromosome damage in human lymphocytes treated with methyl-methanesulphonate, mitomycin C and X-rays |
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Authors: | A Brogger |
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Institution: | Genetics Laboratory, Norsk Hydro''s Institute for Cancer Research, Montebello, Oslo 3, Norway |
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Abstract: | Two hypothese have been put forward in the literature to explain the synergistic effect of caffeine with several mutagens: (1) binding of caffeine to DNA, and (2) inhibition of DNA repair.Autoradiographic studies with 3H- and 14C-labelled caffeine did not support the binding hypothesis. Caffeine enchanced in a synergistic way the amount of chromatid breaks and exchanged induced in human lymphocytes with methyl-methanesulphonate (MMS), mitomycin C (MC) and X-rays. The results are best explained if caffiene inhibits a post-replication repair process, particularly the filling-in of gaps in the newly synthesized DNA. |
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Keywords: | BCNU 1 3-bis(2-chloroethyl)-1-nitrosourea MC mitomycin C MMS methyl methanesulphonate |
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