|
|||||
|
|
Characterization of alanine to valine sequence variants in the Fc region of nivolumab biosimilar produced in Chinese hamster ovary cells |
|
| Authors: | Yantao Li Tuo Fu Tao Liu Huaizu Guo Qingcheng Guo Jin Xu |
| Institution: | 1. International Joint Cancer Institute, Second Military Medical University, Shanghai, China;2. State Key Laboratory of Antibody Medicine and Targeted Therapy, Shanghai, China;3. State Key Laboratory of Antibody Medicine and Targeted Therapy, Shanghai, China;4. Shanghai Zhangjiang Biotechnology Co. |
| Abstract: | |
| Keywords: | DNA sequencing IdeS digests Nivolumab quantitation RT-PCR sequence variants tryptic peptide mapping UPLC-UV/MS/MS |