Serine insertion caused by the ribosomal suppressor SUP46 in yeast |
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| Authors: | B I Ono J W Stewart F Sherman |
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| Affiliation: | Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences Okayama University, Okayama, 700 Japan;Department of Radiation Biology and Biophysics University of Rochester School of Medicine and Dentistry Rochester, N.Y. 14642, U.S.A. |
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| Abstract: | The ribosomal suppressor SUP46 isolated from the yeast Saccharomyces cerevisiae suppresses a broad range of mutations, including at least some UAA, UAG and UGA alleles. The SUP46 suppressor causes the insertion of serine into iso-1-cytochrome c at the site of the UAA mutation in the cyc1-72 allele. It is believed that the altered ribosomes in the SUP46 suppressor allow a serine tRNA to misread UAA codons. |
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