子宫内膜异位症患者血清可溶性B7-H4的水平及意义

目的:探讨子宫内膜异位症患者血清可溶性B7-H4(sB7-H4)的水平及其临床意义。方法:用ELISA夹心法检测43例子宫内膜异位症患者术前血清sB7-H4的水平及40例子宫内膜异位症患者术后血清sB7-H4的水平,同时选取30例体检健康妇女血清sB7-H4水平作为对照。结果:子宫内膜异位症患者血清sB7-H4水平为(36.23±5.67)μg/L,体检健康者血清sB7-H4水平为(31.24±4.56)μg/L,两者比较差异有统计学意义(P0.01)。手术前,子宫内膜异位症患者血清sB7-H4水平为(36.23±5.67)μg/L,明显高于术后(32.54±4.27)μg/L(P0.05)。子宫内膜异位症患者血清sB7-H4水平与CA125水平呈显著正相关(r=0.531,P0.01)。结论:血清可溶性B7-H4可能与子宫内膜异位症的发病有关,检测血清中可溶性B7-H4水平对内异症的辅助诊断和疗效观察可能具有一定的临床意义。

Serumlevel of Soluble B7-H4 (sB7-H4) and its Significance in Endometriosis

Objective： To detect the serum soluble B7-H4 （sB7-H4） level in endometriosis and discuss its clinical significance. Methods： Sandwich ELISA was applied to test the serum sB7-H4 level of 43 cases of endometriosis before operation and 40 cases of endometriosis after operation, as well as 30 cases of healthy women as the control group. Results： The serum sBT-H4 level in endometri- osis patients was （36.23± 5.67 μg/L）, which was significantly higher than that of the healthy controls （31.24± 4.56 μg/L, P〈0.01）. The serum sB7-H4 level in patients with endometriosis before operation was （36.23± 5.67 μg/L）, which was significantly higher than that after operation （32.54 ± 4.27μg/L, P〈0.05）. The serum sB7-H4 level was positively correlated with CA125 in the patients with endometriosis （r=0.531, P〈0.01）. Conclusion： The sB7-H4 may be correlated with the occurrence of endometriosis. Measurement of serum B7-H4 level may contribute to the diagnosis and evaluation of the prognosis of endometriosis.