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New Charge-Deficient Agmatine Analogues |
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| Authors: | A?R?Simonyan N?A?Grigorenko J?Vepsalainen |
| Institution: | (1) Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow, 119991, Russia;(2) Department of Chemistry, University of Kuopio, P.O.Box 1627, FIN-70211 Kuopio, Finland |
| Abstract: | N,N′-Di-Boc-N″-triflylguanidine was demonstrated to be an efficient guanidinylation reagent for O-substituted hydroxylamines. N-(3-Aminooxypropyl)- and N-(3-aminopropoxy)guanidines, previously unknown isosteric and charge-deficient agmatine analogues, have been synthesized. The possibilities of using these compounds in studying polyamine metabolism are discussed. |
| Keywords: | agmatine polyamines O-substituted hydroxylamines |
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