| 毛喉萜对小鼠骨髓细胞和腹腔巨噬细胞表面胰岛素受体和GM－CSF受体的下调作用 |
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| 引用本文： | 林立,沈子威,王又明,丰美福.毛喉萜对小鼠骨髓细胞和腹腔巨噬细胞表面胰岛素受体和GM－CSF受体的下调作用[J].生物物理学报,1994(3). |
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| 作者姓名： | 林立 沈子威 王又明 丰美福 |
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| 作者单位： | 清华大学生物科学与技术系，中国科学院动物研究所生物膜与膜生物工程国家重点实验室 |
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| 摘 要： | 放射性标记受体分析表明毛喉萜（ＦＳＫ）可以降低小鼠骨央细胞和腹腔巨噬细胞表面的胰岛素（ＩＮＳ）和粒细胞－巨噬细胞集落刺激因子（ＧＭ－ＣＳＦ）受体数目，而且对ＧＭ－ＣＳＦ的作用有剂量和时间依赖性，经ＦＳＫ处理的巨噬细胞酸性磷酸酶活性增加，微丝更加舒展。
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| 关 键 词： | 毛喉萜，胰岛素，粒细胞－巨噬细胞，集落刺激因子，受体 |
DOWN REGULATION OF INSULIN AND GM-CSF RECEPTORS IN MURINE BONE MARROW CELLS AND PERITONEAL MACROPHAGES AFFECTED BY FORSKOLIN |
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| Lin Li,Shen Ziwei.DOWN REGULATION OF INSULIN AND GM-CSF RECEPTORS IN MURINE BONE MARROW CELLS AND PERITONEAL MACROPHAGES AFFECTED BY FORSKOLIN[J].Acta Biophysica Sinica,1994(3). |
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| Authors: | Lin Li Shen Ziwei |
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| Abstract: | Radioreceptorassay showed that forskolin could down regulate the nnmbers of insulin and granulocyte-macrophage colony stimulating factor(GM-CSF)receptors in murine bone marrow cells and peritoneal macrophages. And the effect on GM-CSF receptors appeared in a dose and the dependent fashion. The macrophages have showed am increase of acidic phosphatase activity and more stretchy microfilaments after being treated with FSK. |
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| Keywords: | Forskolin Insulin Granulocte-Macrophage Colony Stinulating Factor (GM -CSF) Receptor |
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