Biophysical model of synaptic plasticity dynamics |
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| Authors: | Henry D. I.?Abarbanel mailto:hdia@jacobi.ucsd.edu" title=" hdia@jacobi.ucsd.edu" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Leif?Gibb,R.?Huerta,M. I.?Rabinovich |
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| Affiliation: | (1) Institute for Nonlinear Science, Center for Theoretical Biological Physics, Marine Physical Laboratory (Scripps Institution of Oceanography) and Department of Physics, University of California, San Diego La Jolla, CA 93093-0402, USA;(2) Institute for Nonlinear Science, University of California, San Diego La Jolla, CA 92093-0402, USA;(3) GNB, E.T.S. de Ingenería Informática, Universidad Autónoma de Madrid, 28049 Madrid, Spain |
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| Abstract: | ![]()
We discuss a biophysical model of synaptic plasticity that provides a unified view of the outcomes of synaptic modification protocols, including: (1) prescribed time courses of postsynaptic intracellular Ca2+ release, (2) postsynaptic voltage clamping with presentation of presynaptic spike trains at various frequencies, (3) direct postsynaptic response to presynaptic spike trains at various frequencies, and (4) LTP/LTD as a response to precisely timed presynaptic and postsynaptic spikes. |
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